Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients

Standard VA module lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants.Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with potential promise in this population.We describe Bathroom Cleaners PCSK9i as an efficacious a

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An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity

Summary: HIV-1 hijacks host proteins involved in membrane trafficking, endocytosis, and Dolls autophagy that are critical for virus replication.Molecular details are lacking but are essential to inform on the development of alternative antiviral strategies.Despite their potential as clinical targets, only a few membrane trafficking proteins have be

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Artificial Neural Network (ANN) Approach to Predict Tensile Properties of Longitudinally Placed Fiber Reinforced Polymeric Composites including Interphase

Machine Learning has become prevalent nowadays for predicting data on the mechanical properties of various materials and is widely used in various polymeric applications.In the present study, Artificial Neural Network (ANN), a computational tool is used to predict the elastic modulus of a composite of longitudinally placed fiber-reinforced polymeri

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